Selected Publications
Reens AL, Crooks AL, Su C-C, Nagy TA, Reens DL, Podoll JD, Edwards ME, Yu EW, Detweiler CS. 2018. A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. PLoS Pathog 14:e1007115.
Su C-C, Morgan CE, Kambakam S, Rajavel M, Scott H, Huang W, Emerson CC, Taylor DJ, Stewart PL, Bonomo RA, Yu EW. 2019. Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump. MBio 10.
Detweiler CS. 2020. Infection-based chemical screens uncover host-pathogen interactions. Curr Opin Microbiol 54:43–50.
Klenotic PA, Moseng MA, Morgan CE, Yu EW. 2020. Structural and Functional Diversity of Resistance-Nodulation-Cell Division Transporters. Chem Rev https://doi.org/10.1021/acs.chemrev.0c00621.
Dombach JL, Quintana JLJ, Nagy TA, Wan C, Crooks AL, Yu H, Su C-C, Yu EW, Shen J, Detweiler CS. 2020. A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids. PLoS Pathog 16:e1009119.
Samual C. Allgood, Chih-Chia Su, Amy L. Crooks, Christian T. Meyer, Bojun Zhou, Meredith D. Betterton, Michael R. Barbachyn, Edward W. Yu,
Corrella S. Detweiler. Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host
environment.